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Bioimpedance Measurement for Volume in Patients with Chronic Kidney Disease Participating in the CANPREDDICT Study: Design of a Prospective Study and Results of a Single Centre Pilot

VAL094

Wilkieson TJ|Khandelwal M|Kotsamanes CZ|Gangji AS|Rabbat CG|Levin A|Madore F|Tobe SW|Moist L|Tonelli M|Soroka SD|Hemmelgarn BR|Lok C|Clase CM

Presented at the Canadian Society of Nephrology Conference in Montreal

OBJECTIVE:

  • Volume overload is prevalent in patients with CKD not on dialysis
  • Bioimpedance measurements can be interpreted to assess volume status
  • The resistance (R) – Reactance (Xc) graph method described by Piccoli and colleagues2 can be operationalized as a dichotomous assessment of volume overload (Figure 1)
  • 50% of participants in the CANPREDDICT study will consent to the bioimpedance substudy.

RESULTS:

Participants

  • 43% women
  • Mean age 66 years
  • 34 consecutive CANPREDDICT participants were approached at their first return visit between 2009 December 09 and 2010 April 20
  • 28 (82%) participated, 4 declined and 2 deferred their decision to their next visit
  • 43% patients volume overloaded by the RXc graph method (Figure 2)
  • Kappa was 1.0 for inter-observer agreement in graph interpretation

CONCLUSION:

  • The RXc graph method described by Piccoli and colleagues can be reliably operationalized into a dichotomous assessment
  • Volume overload according to the RXc method is prevalent in patients with CKD not on dialysis
  • The study appears to be feasible

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