was successfully added to your cart.

Insulin-requiring diabetes in Ethiopia: Associations with Poverty, Early Undernutrition and Anthropometric Disproportion

Fekadu S|Yigzaw M|Alemu S|Dessie A|Fieldhouse H|Girma T|Trimble ER|Phillips DIW|Parry EHO
European Journal of Clinical Nutrition (2010), 1–7
Background/Objectives: Most insulin-requiring diabetes patients in Ethiopia have an atypical form of the disease, which resembles previous descriptions of malnutrition-related diabetes. As so little is known about its aetiology, we have carried out a case–control study to evaluate its social and nutritional determinants.
Subjects /Methods: Men and women with insulin-requiring diabetes (n = 107), aged 18–40 years, were recruited in two centres, Gondar and Jimma, 750km northwest and 330km southwest of the capital, Addis Ababa, respectively. Controls of similar age and sex (n = 110) were recruited from patients attending other hospital clinics.
Results: Diabetes was strongly associated with subsistence farming, odds ratio = 3.5 (95% confidence interval: 1.5–7.8) and illiteracy/low levels of education, odds ratio = 4.0 (2.0–8.0). Diabetes was also linked with a history of childhood malnutrition, odds ratio = 5.5 (1.0–29.0) the mother’s death during childhood, odds ratio = 3.9 (1.0–14.8), and markers of poverty including poorer access to sanitation (P = 0.004), clean water (P = 0.009), greater overcrowding (P = 0.04), increased distance from the clinic (P = 0.01) and having fewer possessions (P = 0.01). Compared with controls, people with diabetes had low mid upper arm circumference, body mass index (BMI) and fat/lean body mass (P<0.01). In addition, men with the disease tended to be shorter, were lighter (P = 0.001), with reduced sitting height (P = 0.015) and reduced biacromial (P = 0.003) and bitrochanteric (P = 0.008) diameters.
Conclusions: Insulin-requiring diabetes in Ethiopia is strongly linked with poor education and markers of poverty. Men with the disease have associated disproportionate skeletal growth. These findings point towards a nutritional aetiology for this condition although the nature of the nutritional deficiency and its timing during growth and development remains obscure.
Download Paper – Insulin-requiring diabetes in Ethiopia: associations with poverty, early undernutrition and anthropometric disproportion

Download My Free Paper

download without emailclose this window